C16 - PLENARY: Bridging Preclinical to Clinical Research With Artificial Intelligence (AI) and Digital Biomarkers: Current Landscape, Vision, and the Collaborative Path Toward Improved Translation

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Advances in sensor technologies, wearable devices, computer vision, and AI- informed digital measures are providing an opportunity to improve nonclinical to clinical translation in both directions. Better insights into the onset and progression of human diseases better inform animal modeling approaches. Digital biomarkers facilitate continual measurements of patients at home and animals within home cage environments. This session will rationalize that digital biomarkers offer holistic, dynamic, and actionable insights into disease modeling and drug assessment, enabling improved translatability, accelerated throughput, heightened utility, and increased reproducibility. In the preclinical research environment, such technologies also enable less human interaction and disruption to the animal and improved detection of health/welfare events and earlier intervention.